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Sodium starch glycolate

Name: Sodium starch glycolate
Brand: KPM Corporation
Price: 50.0 INR
Availability: InStock

Price 50.0 INR/ Kilograms

Get a Price/Quote

MOQ : 1 Kilograms

Sodium starch glycolate Specification

Usage
Used in tablet manufacturing to promote rapid disintegration

CAS No
9063-38-1

Appearance
White or almost white powder

Ingredients
Sodium salt of carboxymethyl ether of starch

Poisonous
Non-poisonous

Purity
>98%

Ph Level
5.5 - 7.5 (1% w/v aqueous solution)

Product Type
Organic Chemical

Properties
White or almost white, free-flowing powder; odorless or almost odorless; insoluble in most organic solvents; swells rapidly in water

Application
Superdisintegrant in pharmaceutical formulations

Grade
Pharmaceutical Grade

Molecular Formula
(C6H10O5)x(C2H4O2Na)y

Solubility
Practically insoluble in ethanol, but swells in water

Storage
Store in tightly closed container in a cool, dry place

HS Code
35051000

Melting Point
Decomposes before melting

EINECS No
618-587-2

Shape
Fine, free-flowing powder

Molecular Weight
Variable, depending on polymer chain (typically around 100,000-1,000,000 g/mol)

Shelf Life
2 years

Taste
Tasteless or slightly saline

Physical Form
Powder

Density
0.60 Gram per cubic centimeter(g/cm3)

Structural Formula
Derived from starch and sodium glycolate; represented as a cross-linked carboxymethyl starch sodium salt

Smell
Odorless or almost odorless

Packing
25 kg HDPE drum/bag

Residual Solvent
Complies with relevant pharmacopeial limits

Category
Pharmaceutical excipient

Sodium Content
2.8% to 4.2%

pH of 1% Solution
5.5 - 7.5

Heavy Metals
Not more than 20 ppm

Standard
Complies with IP/BP/USP specifications

Microbial Limits
Complies with pharmacopeial standards for total aerobic microbial count and total yeast & mold count

Compatibility
Compatible with most pharmaceutical excipients

Particle Size
90% passes through 100 mesh sieve

Bulk Density
0.50 - 0.60 g/cm3

Function
Superdisintegrant

Synonyms
SSG, Sodium starch glycollate

Loss on Drying
Not more than 10.0% (when dried for 2 hrs at 130C)

Sodium starch glycolate Trade Information

Minimum Order Quantity
1 Kilograms

Delivery Time
1 Week

About Sodium starch glycolate

Sodium Starch Glycolate (SSG) powder is a vital pharmaceutical excipient, acting as a superdisintegrant that rapidly swells and breaks down tablets/capsules in water, releasing medicine faster for better absorption; it's a white, fine, free-flowing powder from starch, also used as a binder, gelling, or suspending agent in solid dosage forms, ensuring drug efficacy.

Key Characteristics:

Appearance: Fine, white to off-white, odorless powder.
Origin: Derived from starch (potato, corn, rice) and modified.
Function: Primary role as a superdisintegrant in tablets and capsules.
Mechanism: Rapidly absorbs water, swells significantly, creating pressure to disintegrate the dosage form.

Uses in Pharmaceuticals:

Disintegration: Breaks down tablets/capsules quickly for faster drug release.
Binding: Can act as a binder to hold tablet ingredients together.
Suspending Agent: Helps keep insoluble ingredients dispersed.
Gelling Agent: Forms gels in liquid formulations.

Benefits:

Enhances drug dissolution and bioavailability.
Suitable for direct compression and wet granulation.
Provides excellent fluidity for manufacturing

Superior Disintegration Performance

Sodium starch glycolate excels in promoting rapid tablet breakup, ensuring efficient release of the active pharmaceutical ingredient. Its high swelling capacity in water and ability to disperse quickly make it integral to modern tablet formulations, where patient convenience and therapeutic efficacy are top priorities.

Quality and Compliance Assured

Manufactured according to IP, BP, and USP specifications, SSG meets strict quality standards for purity, heavy metal content, residual solvents, and microbiological limits. Each batch is carefully monitored to ensure bulk density, particle size distribution, and sodium content meet pharmacopeial requirements.

Safe and Versatile Excipient

Non-toxic and practically odorless, SSG is compatible with most excipients and is easily integrated into various formulations. Its insolubility in organic solvents and excellent swelling behavior in water make it a versatile and essential additive in pharmaceutical industries.

FAQ's of Sodium starch glycolate:

Q: How is Sodium Starch Glycolate used in tablet manufacturing?

A: Sodium starch glycolate is primarily used as a superdisintegrant in tablet formulations. It is added to the tablet blend, where it rapidly swells upon contact with water, helping tablets break apart quickly for efficient drug release.

Q: What are the key benefits of using SSG in pharmaceutical applications?

A: SSG ensures fast tablet disintegration, enhancing the bioavailability of the active ingredient. Its high purity, non-toxicity, compatibility with other excipients, and compliance with global pharmacopeial standards make it a preferred choice for formulators.

Q: Where should Sodium Starch Glycolate be stored for optimal shelf life?

A: To maintain its stability and effectiveness, Sodium starch glycolate should be stored in a tightly closed container in a cool, dry place. Proper storage conditions help preserve its physical and chemical properties for up to two years.

Q: What is the recommended particle size specification for Sodium starch glycolate?

A: For optimal performance, 90% of Sodium starch glycolate particles should pass through a 100 mesh sieve, ensuring uniform distribution and consistent disintegration results in tablet manufacturing.

Q: When does SSG comply with pharmacopeial requirements for use in medications?

A: SSG must meet specific quality parameters, including loss on drying not more than 10.0%, sodium content between 2.8% and 4.2%, and compliance with residual solvents and microbial limits as specified by IP/BP/USP standards, before it is approved for use in pharmaceuticals.

Q: How compatible is SSG with other excipients and active ingredients?

A: Sodium starch glycolate is highly compatible with most pharmaceutical excipients and active ingredients, which allows for trouble-free formulation and production across a wide range of solid dosage forms.

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